There is no definitive answer, but most people believe that it is not advisable to hit on a 12 in blackjack. This is because the odds of hitting on a 12 are about 1 in 22, or just over 5%.
In comparison, hitting on a 10 or 11 is much more likely, and hitting on a blackjack 21 is virtually guaranteed.
Additionally, there are other factors to consider when playing blackjack. For example, if you are playing with someone else in a casino, it can be helpful to establish some ground rules before hand.
These might include not hitting on 12s and other low cards, since this will give your opponents an advantage.